Table 3.

Gene Functional Classification Result (PANTHER 14.1) of over-expressed genes in ST cells from SNEB animals. Main pathways and ontology annotation groups enriched are shown (over-representation statistical test)

PANTHER Classification	fold Enrichment	FDR	genes
PANTHER Pathways
Inflammation mediated by chemokine and cytokine signaling pathway (P00031)	2.15	5.26E-03	ACTA2, JUNB, CAMK2B, CCL11, MYH11, ACTG2,, ITPR2, PRKCZ, MYH14, ACTA1, PLCB4, MYLK, PAK4, PLCH1, CCL4, CCL3
Wnt signaling pathway (P00057)	2.1	2.58E-02	ACTG2, FZD5, PLCB4, CDH3, PRKCZ, CDH1, ACTA1, CTBP2, ITPR2, FRZB, ANKRD6, ACTA2
Cadherin signaling pathway (P00012)	2.21	3.43E-02	ACTA2, CDH3, ACTG2, FRK, FZD5, ACTA1, CDH1, ERBB3
Integrin signaling pathway (P00034)	1.72	1.51E-02	ACTG2, ITGB4, FRK, RAP2A, ITGB6, FLNA, COL4A6, ACTA1, FLNB, COL4A5, ACTA2
Gap junction trafficking and regulation (R-BTA-157858)	4.98	1.16E-02	GJB4, GJB1, GJB3, GJB5
Cytoskeletal regulation by Rho GTPase (P00016)	3	7.29E-03	ACTA2, MYH11, ACTG2, ARHGAP1, MYH14, ACTA1, MYLK, PAK4
PANTHER Biological Process
cytoskeleton-dependent intracellular transport (GO:0030705)	3.49	6.77E-03	RP1, ACTA2, SPAG17, ACTG2, BICDL2, JHY, JHY, ACTA1, TEKT4, CENPJ, DYNC1I1, CFAP54, CCDC39, DRC1, BICDL1
cilium movement (GO:0003341)	7.88	7.77E-03	DNAH7, ZBBX, TACR1, TEKT4, CCDC39, DNAH11, DRC1
PANTHER Molecular Function
transmembrane transporter activity (GO:0022857)	1.55	1.54E-02	LRRC26, SLC45A2, P2RX3, LRRC38, KCNG1, SLC36A2, SLC38A11, KCNMB1, CLCN3, GRIN1, ATP1B1, ATP2B4, SLC18A2, SLC5A9, SLC29A2, CACNB2, GRIA3, KCNF1, SLC5A10, SGK2, LRRIQ1, ATP6V1G3, SLC35A3, SLC4A7, SLC10A1, KCNH2, TMC5, SLC31A2, SLC34A2