Fig. 1.

IL-1β treatment triggered the upregulation of circ-SPG11 in CHON-001 cells. A Circ-SPG11 expression was detected by qRT-PCR in OA tissues (n = 29) and normal tissues (n = 23). B Circ-SPG11 expression was examined by qRT-PCR in CHON-001 cells treated by 0 ng/mL, 5 ng/mL, and 10 ng/mL, 15 ng/mL of IL-1β for 24 h. C Circ-SPG11 expression was measured by qRT-PCR in CHON-001 cells treated by 10 ng/mL of IL-1β for 0 h, 12 h, 24 h, and 48 h. D QRT-PCR was devoted to testing the expression of circ-SPG11, U6, and GAPDH in the cytoplasm and nuclear of CHON-001 cells. E QRT-PCR was used to determine the expression of circ-SPG11 and Linear SPG11 in CHON-001 cells treated by RNase R. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001