Table 1. 0.5% tetracaine induced corneal anesthesia in rats and effect of pentadecapeptide BPC 157 (0.4 µg/eye), L-NAME (0.1 mg/eye) and/or L-arginine (2 mg/eye) administered alone or in combination after complete corneal anesthesia was established, at 1 min after 0.5% tetracaine.

Pentadecapeptide BPC 157 (0.4 µg/eye), L-NAME (0.1 mg/eye), L-arginine (2 mg/eye), administered alone and in combination after complete corneal anesthesia was established, at 1 min after 0.5% tetracaine	Duration of 0.5% tetracaine corneal anesthesia
	T1 (min), mean ± SD	T4 (min), mean ± SD
Saline	59±5.2	109±12.5
BPC 157	45±4.6*	94±7.0*
L-arginine	51±8.5*	90±5.3*
L-arginine + BPC 157	34±5.8*#	72±5.8*#
L-NAME	84±7.7*	126±8.4*
L-NAME + BPC 157	65±7.1#	100±9.4#
L-arginine + L-NAME	73±8.6*+	123±8.2*+
L-arginine + L-NAME + BPC 157	44±3.9*#	91±8.4*#

T1 = time point when blink response to maximal corneal stimulation appeared again; T4 = time point when corneal sensitivity returned to baseline values; T1-T4 = complete corneal anesthesia duration (minutes, mean ± SD); *p<0.05 vs. saline (control); ^#p<0.05 vs. corresponding ‘non-BPC 157 group’; ⁺p<0.05 vs. corresponding ‘L-NAME-group’; Mann-Whitney test for independent samples followed by Benjamini and Hochberg procedure to control the false discovery rate (FDR)