Table 3. 0.5% tetracaine corneal anesthesia in rats and effect of pentadecapeptide BPC 157 (0.4 µg/eye), L-NAME (0.1 mg/eye) and/or L-arginine (2 mg/eye) administered alone and in combination after complete corneal anesthesia was established, at 1 min after 0.5% tetracaine.

Pentadecapeptide BPC 157 (0.4 µg/eye), L-NAME (0.1 mg/eye), L-arginine (2 mg/eye) administered alone and in combination after complete corneal anesthesia was established, at 1 min after 0.5% tetracaine	At 30 min	At 60 min	At 150 min
Saline	2.5±0.5	2.0±0.6	2.0±0.6
BPC 157	6.5±0.5*	5.0±0.6*	5.5±0.5*
L-arginine	5.5±0.5*	3.5±0.5*	3.0±0.9
L-arginine + BPC 157	5.5±0.5*	6.0±0.6*	6.0±0.6*
L-NAME	3.5±0.5*	2.5±0.5	1.0±0.6*
L-NAME + BPC 157	4.0±0.6*	4.5±0.5*	5.5±0.5*
L-arginine + L-NAME	4.0±0.6*	4.0±0.9*	5.0±0.9*
L-arginine + L-NAME + BPC 157	4.5±0.8*	4.5±0.5*	5.5±0.5*

Standard Schirmer tracks using 2 mm-wide test strips cut from Schirmer test paper to fit the size of the rat’s eye were inserted 1 mm into the inferior conjunctival fornix and placed for 5 minutes after which results in millimeters (mean ± SD) were read; *p<0.05 vs. saline (control); Mann-Whitney test for independent samples followed by Benjamini and Hochberg procedure to control false discovery rate (FDR)