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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Biotechnol Bioeng. 2020 Jul 5;117(10):3136–3149. doi: 10.1002/bit.27474

FIGURE 6.

FIGURE 6

Evaluation of how integrated stress response (ISR) affects cellular survival and function. (a) Determination of cellular survival following 24-hr ischemic stress (serum withdrawal and incubation under 2% O2 tension). (b) Caspase 3/7 activity following ischemic and aggregation culture. (c) Colony-forming unit-fibroblasts (CFU-F) with small-molecule inhibition of ISR for planar cells. Data represent the mean of at least three independent determinations; errors represent the standard error in the mean. *p < .05, ***p < .01