TABLE 2.
Results of multiple linear models of seasonally adjusted log monthly counts of submitted and completed trials
| Characteristic | Submitted | Completed | Primary outcome completed | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Beta | 95% CI | p value | Beta | 95% CI | p value | Beta | 95% CI | p value | |
| 2019 baseline | 0.22 | 0.07, 0.36 | 0.003 | 0.30 | 0.21, 0.40 | <0.001 | 0.33 | 0.23, 0.43 | <0.001 |
| Time | 0.01 | −0.02, 0.03 | 0.6 | −0.03 | −0.05, −0.01 | <0.001 | −0.03 | −0.05, −0.01 | 0.014 |
| COVID indicator | −0.03 | −0.10, 0.05 | 0.5 | −0.34 | −0.42, −0.27 | <0.001 | −0.37 | −0.45, −0.29 | <0.001 |
| Pharma | — | — | — | — | — | — | |||
| Academic | 0.00 | −0.04, 0.04 | >0.9 | 0.00 | −0.03, 0.03 | >0.9 | 0.00 | −0.03, 0.03 | >0.9 |
| United States | — | — | — | — | — | — | |||
| Asia | 0.04 | 0.00, 0.09 | 0.045 | −0.01 | −0.04, 0.03 | 0.7 | 0.00 | −0.04, 0.04 | 0.8 |
| Europe | 0.01 | −0.04, 0.05 | 0.8 | 0.01 | −0.03, 0.05 | 0.6 | 0.00 | −0.04, 0.04 | >0.9 |
| COVID* Academic | 0.03 | −0.07, 0.12 | 0.5 | −0.15 | −0.23, −0.07 | <0.001 | −0.23 | −0.31, −0.14 | <0.001 |
Abbreviations: CI, confidence interval; COVID, coronavirus disease; Pharma, pharmaceutical.
Bolded values represent p‐values that are less than 0.05.