Table 2.
Summary of pharmacokinetic parameters of tegoprazan after a single oral administration of tegoprazan 50 mg in the fasted state, at 30 min before a high‐fat meal or at 30 min after a high‐fat meal
| PD parameter a |
Baseline (N = 12) |
Fasted (N = 12) |
30 min before meal (N = 12) |
30 min after meal (N = 12) |
|---|---|---|---|---|
| % Time pH ≥4, % | 7.2 ± 3.6 | 49.1 ± 11.6 | 53.8 ± 13.4 | 61.1 ± 7.6 |
| Median pH | 1.8 ± 0.1 | 3.8 ± 1.0 | 4.3 ± 1.1 | 4.6 ± 0.3 |
| Mean pH | 2.1 ± 0.2 | 4.0 ± 0.4 | 4.2 ± 0.5 | 4.4 ± 0.3 |
| Δ% Time pH ≥4, % | ‐ | 42.0 ± 12.1 | 46.6 ± 13.3 | 54.0 ± 7.1 |
| ΔMedian pH | ‐ | 1.9 ± 1.0 | 2.5 ± 1.1 | 2.7 ± 0.4 |
| ΔMean pH | ‐ | 1.9 ± 0.4 | 2.0 ± 0.5 | 2.2 ± 0.3 |
Abbreviation: PD, pharmacodynamic.
a
All PD parameters are expressed as mean ± SD; Δ represents baseline corrected pharmacodynamic parameters.