Table 5.
Missing baseline data | Model name | Training data (n) | CV/test | r | r 2 | P value | MAE |
---|---|---|---|---|---|---|---|
None | AG | 13 936 | CV | 0.75 | 0.56 | 0.0001 | 0.65 |
test | 0.74 | 0.55 | 0.0001 | 0.69 | |||
Genotype | ANG | 56 717 | CV | 0.70 | 0.49 | 0.0001 | 0.71 |
test | 0.68 | 0.46 | 0.0001 | 0.73 | |||
Time on therapy | AG(−ToT) | 19 080 | CV | 0.74 | 0.55 | 0.0001 | 0.65 |
test | 0.72 | 0.52 | 0.0001 | 0.70 | |||
Genotype/time on therapy | ANG(−ToT) | 50 270 | CV | 0.69 | 0.48 | 0.0001 | 0.72 |
test | 0.67 | 0.45 | 0.0001 | 0.74 | |||
Genotype/CD4 count | ANG(−CD4) | 62 940 | CV | 0.70 | 0.49 | 0.0001 | 0.71 |
test | 0.69 | 0.48 | 0.0001 | 0.75 | |||
Genotype/time on therapy/CD4 count | ANG(−ToT −CD4) | 56 717 | CV | 0.68 | 0.46 | 0.0001 | 0.74 |
test | 0.66 | 0.44 | 0.0001 | 0.75 |
CV, cross-validation; test, independent testing; MAE, mean absolute error - the difference between predicted and actual change in plasma viral load (log10 copies HIV RNA/mL).