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. 2021 Apr 1;76(7):1898–1906. doi: 10.1093/jac/dkab078

Table 7.

Summary results for the in silico analyses

Modelling for all test cases
Modelling for failures only
Missing baseline data Model name Effective alternatives predicted (%)
Superior alternatives predicted (%)
Effective alternatives predicted (%)
Superior alternatives predicted (%)
S R S S R S
Classifier models: response defined as follow-up plasma viral load of <50 copies/mL HIV RNA

None CG 91 77 98 87 68 100
Genotype CNG 94 80 100 91 71 100
Time on therapy CG(−ToT) 91 76 99 86 65 100
Genotype/time on therapy CNG(−ToT) 98 84 100 96 77 100
Genotype/CD4 count CNG(−CD4) 95 84 99 91 77 100
Genotype/time on therapy/CD4 count CNG(−ToT −CD4) 98 86 100 97 79 100

Absolute models: response defined as follow-up plasma viral load of <400 copies/mL HIV RNA

None AG 92 84 96 85 73 100
Genotype ANG 95 82 98 91 67 100
Time on therapy AG(−ToT)a 93 86 97 85 74 100
Genotype/time on therapy ANG(−ToT)a 100 96 98 99 92 100
Genotype/CD4 count ANG(−CD4) 96 88 99 92 78 100
Genotype/time on therapy/CD4 count ANG(−ToT −CD4) 97 90 98 95 81 100

S, standard drug list; R, restricted drug list.

a

Previously published.15