Table 7.
Modelling for all test cases |
Modelling for failures only |
||||||
---|---|---|---|---|---|---|---|
Missing baseline data | Model name | Effective alternatives predicted (%) |
Superior alternatives predicted (%) |
Effective alternatives predicted (%) |
Superior alternatives predicted (%) |
||
S | R | S | S | R | S | ||
Classifier models: response defined as follow-up plasma viral load of <50 copies/mL HIV RNA | |||||||
| |||||||
None | CG | 91 | 77 | 98 | 87 | 68 | 100 |
Genotype | CNG | 94 | 80 | 100 | 91 | 71 | 100 |
Time on therapy | CG(−ToT) | 91 | 76 | 99 | 86 | 65 | 100 |
Genotype/time on therapy | CNG(−ToT) | 98 | 84 | 100 | 96 | 77 | 100 |
Genotype/CD4 count | CNG(−CD4) | 95 | 84 | 99 | 91 | 77 | 100 |
Genotype/time on therapy/CD4 count | CNG(−ToT −CD4) | 98 | 86 | 100 | 97 | 79 | 100 |
| |||||||
Absolute models: response defined as follow-up plasma viral load of <400 copies/mL HIV RNA | |||||||
| |||||||
None | AG | 92 | 84 | 96 | 85 | 73 | 100 |
Genotype | ANG | 95 | 82 | 98 | 91 | 67 | 100 |
Time on therapy | AG(−ToT)a | 93 | 86 | 97 | 85 | 74 | 100 |
Genotype/time on therapy | ANG(−ToT)a | 100 | 96 | 98 | 99 | 92 | 100 |
Genotype/CD4 count | ANG(−CD4) | 96 | 88 | 99 | 92 | 78 | 100 |
Genotype/time on therapy/CD4 count | ANG(−ToT −CD4) | 97 | 90 | 98 | 95 | 81 | 100 |
S, standard drug list; R, restricted drug list.
Previously published.15