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. Author manuscript; available in PMC: 2021 Jun 18.
Published in final edited form as: Science. 2019 Jun 7;364(6444):956–959. doi: 10.1126/science.aaw7567

Fig. 2. Using principles of organogenesis to generate cellular complexity during organoidgenesis.

Fig. 2.

The upper panel shows some of the main stages that drive assembly of organ primordia. The middle line indicates additional cell types that get incorporated into developing organs (vascular cells, nerves, immune cells) and how these cell types have been experimentally incorporated into developing organoids (lower panel). After transplantation, organoids can become vascularized by the host and continue to grow in size and undergo tissue morphogenesis.