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. 2021 Jun 4;12:684052. doi: 10.3389/fimmu.2021.684052

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Copyright © 2021 Walcher, Kistenmacher, Sommer, Böhlen, Ziemann, Dehmel, Braun, Tretbar, Klöß, Schambach, Morgan, Löffler, Kämpf, Blumert, Reiche, Beckmann, König, Standfest, Thoma, Makert, Ulbert, Kossatz-Böhlert, Köhl, Dünkel and Fricke

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Irradiation decreases surface expression of CD56. (A+B): NK-92 (A, n = 4) and CD123-CAR-NK-92 cells (B, n = 7) were stained with anti-human CD56 antibody. Surface expression levels of CD56 are indicated as CD56^low (black) and CD56^high (grey). Representative contour plots of non-irradiated (control), LEE-irradiated, and gamma-irradiated cells on day 3 post-irradiation are shown. (C) Analysis of the CD56^low subpopulation of NK-92 (left) and CD123-CAR-NK-92 cells (right) regarding apoptosis: 7-AAD^-/Annexin V^- (lightest grey), 7-AAD⁺/Annexin V^- (dark grey), 7-AAD⁺/Annexin V⁺(light grey) and 7-AAD⁻/Annexin V⁺ (black). Representative contour plots of non-irradiated (control), LEE-irradiated, and gamma-irradiated cells on day 3 post-irradiation are shown. Values are indicated as means ± SEM, statistical significance is symbolized by asterisks (* for p ≤ 0.05 and ** for p ≤ 0.01, Kruskal-Wallis test adjusted for multiple comparisons by Dunn’s test).