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. 2021 Jun 4;12:602581. doi: 10.3389/fpsyg.2021.602581

TABLE 1.

DSM-5 diagnostic criteria for Major Depressive Disorder.

DSM-5 criteria Primary PHQ-9 items
Five or more symptoms including depressed mood and/or loss of interest or pleasure, during a 2-week period.
Depressed mood (e.g., feels sad, empty, hopeless, tearful). Y Item 2. Feeling down, depressed, or hopeless.
Markedly diminished interest or pleasure. Y Item 1. Little interest or pleasure in doing things.
Weight loss when not dieting or weight gain. N Item 5. Poor appetite or overeating.
Insomnia or hypersomnia. N Item 3. Trouble falling or staying asleep, or sleeping too much.
Psychomotor agitation or retardation (observable by others). N Item 8. Moving or speaking so slowly that other people could have noticed? Or the opposite—being so fidgety or restless that you have been moving around a lot more than usual.
Fatigue or loss of energy. N Item 4. Feeling tired or having little energy.
“Feeling worthless or excessive, delusional or inappropriate guilt. N Item 6. Feeling bad about yourself—or that you are a failure or have let yourself or your family down.
Fogginess, being unfocused, or indecisive. N Item 7. Trouble concentrating on things, such as reading the newspaper or watching television.
Thought about harming yourself or suicide. N Item 9. Thoughts that you would be better off dead or of hurting yourself in some way.

PHQ-9: Patient Health Questionnaire 9 (Kroenke et al., 2001).

DSM-5: Diagnostic and Statistical Manual of Mental Disorders.

Primary symptoms are marked with Y.