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. 2021 Jun 4;12:643546. doi: 10.3389/fgene.2021.643546

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Copyright © 2021 Zhang, Xu, Tian, Liu, Hou, Zeng, Chen, Liu, Li, Li, Zuo, Tang and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Photographs of affected individuals. (A) WS01-II:1 presented normal pigmentation of the iris, hair, and skin, and without dystopia canthorum. (B) B1, WS02-III:2; B2, WS02-III:1; B3, WS02-II:2; and B4, WS02-I:1. They all presented dystopia canthorum, while WS02-III:2 has bilateral blue iris and WS02-III:1 has unilateral. (C) C1, WS03-II:1; C2, WS03-II:2; and C3, WS03-I:2. They presented bilateral or unilateral blue iris. (D) WS04-II:1 presented complete bilateral blue iris. (E) E1, WS05-IV:1 presented complete bilateral blue iris. E2, WS05-III:1 presented complete bilateral blue iris and special brown freckles on the face. (F) F1, F2, WS06-II:1 presented yellow hair and normal iridis color. (G) G1, WS07-II:1 presented unilateral blue iris and dystopia canthorum. G2, WS07-II:1 presented dystopia canthorum.