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. 2021 Jun 4;12:681615. doi: 10.3389/fimmu.2021.681615

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Copyright © 2021 Ziblat, Iraolagoitia, Nuñez, Torres, Secchiari, Sierra, Spallanzani, Rovegno, Secin, Fuertes, Domaica and Zwirner

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TCGA analyses shows that CD85j, CD45, CD48 and PD-1 are overexpressed in ccRCC and associated with a NK cell signature. Analysis of expression of CD85j (A), CD45 (B), CD48 (C) and PD-1 (D) in ccRCC (n=533) compared to normal kidney (n=72) using the TIMER platform with data deposited in the TCGA. Also, a correlation analysis between the expression of CD85j (E), CD45 (F), CD48 (G) and PD-1 (H) and a NK cell signature (established by the overexpression of a group of 11 NK cell-associated genes that are not expressed or are weakly expressed on CD8⁺ T cells: NCR1, XCL2, IL2RB, KLRF1, KIR2DL4, KLRC3, XCL1, NKG7, CTSW, NCR3, and IL18RAP) in ccRCC was performed using the GEPIA2 platform. ***p < 0.001.