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Summary Macaque Efficacy Data with Oral Tenofovir Alafenamide (TAF) and FTC/TAF
| Rectal challenge (rhesus macaques) | Vaginal challenge (pigtail macaques) | |
|---|---|---|
| TAF | Supra therapeutic dose 13.7 mg/kg | Clinical dose (1.5 mg/kg) |
| ∼1,600 fmol/106 PBMC | ∼300 fmol/106 PBMC | |
| ∼1,000 fmol/106 rectal lymphocytes | ∼5 fmol/mg of vaginal tissue | |
| No protection | 58%–73% efficacy | |
| FTC/TAF | Clinical dose (1.5 mg/kg) | Clinical dose (1.5 mg/kg) |
| 100% efficacy | 91%–100% efficacy |
PBMC, peripheral blood mononuclear cell.
