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. 2021 Jun 1;37(6):489–501. doi: 10.1089/aid.2020.0222

Table 2.

Study Expectations and Previous HIV Cure-Related Research Experiences Among AIDS Clinical Trials Group A5345 Cohort A Respondents, by Intensively Monitored Antiretroviral Pause Status, n = 32

Question Pre-IMAP, n = 16 Post-IMAP, n = 16 Yes n (%) No n (%) Don't know n (%) Missing n (%) p valuea
Are you generally interested in HIV cure research?
 Pre-IMAP 16 (100%) 0 (0%) 0 (0%) 0 (0%) N/A
 Post-IMAP 16 (100%) 0 (0%) 0 (0%) 0 (0%)
Have you previously participated in an HIV treatment study?
 Pre-IMAP 8 (50%) 6 (38%) 2 (13%) 0 (0%) .882
 Post-IMAP 6 (38%) 8 (50%) 2 (13%) 0 (0%)
Have you previously participated in an HIV cure study?
 Pre-IMAP 5 (31%) 9 (56%) 2 (13%) 0 (0%) .272
 Post-IMAP 10 (63%) 5 (31%) 1 (6%) 0 (0%)
Have you previously participated in a study that involved pausing your anti-HIV medications?
 Pre-IMAP 1 (6%) 15 (94%) 0 (0%) 0 (0%) 1.000
 Post-IMAP 1 (6%) 15 (94%) 0 (0%) 0 (0%)
Were you satisfied with the informed consent process?
 Pre-IMAP 15 (94%) 0 (0%) 0 (0%) 1 (6%) 1.000
 Post-IMAP 15 (94%) 1 (6%) 0 (0%) 0 (0%)
Are there any risks to you from participating in this study?
 Pre-IMAP 13 (81%) 2 (13%) 1 (6%) 0 (0%) 1.000
 Post-IMAP 13 (81%) 3 (19%) 0 (0%) 0 (0%)
Do you have any concerns about HIV inside your body increasing if you stop your anti-HIV medications?
 Pre-IMAP 4 (25%) 11 (69%) 1 (6%) 0 (0%) .357
 Post-IMAP 8 (50%) 7 (44%) 1 (6%) 0 (0%)
Are there any direct benefits to you from participating in this study?
 Pre-IMAP 8 (50%) 6 (38%) 2 (13%) 0 (0%) .408
 Post-IMAP 11 (69%) 5 (31%) 0 (0%) 0 (0%)
Will you receive a health benefit from being in this study?
 Pre-IMAP 6 (38%) 6 (38%) 4 (25%) 0 (0%) .035
 Post-IMAP 1 (6%) 13 (81%) 2 (13%) 0 (0%)

Pre- and post-IMAP groups are independent samples.

a

Fisher's exact test p-value (missing excluded).

IMAP, intensively monitored antiretroviral pause; N/A, not applicable.