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. 2021 Jun 4;12:658428. doi: 10.3389/fimmu.2021.658428

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Copyright © 2021 Sui, Li, Venzon and Berzofsky

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The heatmap and principal component analysis (PCA) plot of ACE2 and type I interferons after spike protein treatment. Heatmap (A) and PCA plot (B) were built up using the data obtained from BAL fluids of 20 naïve macaques treated with 1µg/ml of spike protein S1 for 20 hrs using Qlucore Omics Explorer software. The missing data (due to the low copy number of some genes) was filled with black squares. The scale in (A) is the relative expression level of the genes. The numbers below the heatmap, and in the PCA plot are the animal IDs.