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. 2021 Jun 4;11:649029. doi: 10.3389/fonc.2021.649029

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Copyright © 2021 Cao, Li, He, Jin, Li, Chen, Xu, Sun, Xiong and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FHL3 knockdown reversed the EMT process in gastric cancer. (1) The relationship between FHL3 and EMT-associated transcriptional factors (Snail1, Slug, Twist), and EMT markers (N-cadherin, E-cadherin and Vimentin) (A_1–6); (2) FHL3 knockdown reversed the EMT process and was verified by western blot in FHL3-NC and SH1 cell lines (B_1–7); (3) The effects of FHL3 knockdown in migration and invasion were explored by transwell (200× magnification) and wound healing assay (40× magnification) in in OHP-resistance FHL3-NC and SH1 cell lines (C, D_1–2 and E_1–2).