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. 2021 Jun 4;11:649029. doi: 10.3389/fonc.2021.649029

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Copyright © 2021 Cao, Li, He, Jin, Li, Chen, Xu, Sun, Xiong and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FHL3-mediated gastric cancer OHP resistance was verified in subcutaneous tumor model. (1) The tumors were harvested, and the tumor volume and weight in vivo were investigated (A, C and D), FHL3 knockdown could sensitize the efficacy of OHP treatment and inhibit tumor growth; (2) Tumor volume variation during 14 days of OHP treatment (B); (3) The ki-67 staining assay (100× magnification) was performed to show the cancer cell proliferation of every group (E).