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. 2021 Jun 18;16(6):e0252411. doi: 10.1371/journal.pone.0252411

Table 5. Presenting symptoms and signs during the first 24 hours of admission.

n (%) or median [IQR]
All patients Non-severe disease Severe disease p-value
n = 223(%) n = 168(%) n = 55(%)
Days from symptom onset to presentation, median 5[8–3] 5[3–8] 7[2–9] 0.9277
Subjective
 Respiratory symptomsa 192(86.1) 140(83.3) 52(94.6) 0.0370*
 GI symptomsb 118(52.9) 88(52.4) 30(54.6) 0.7801
 Systemic symptomsc 178(79.8) 136(81.0) 42(76.4) 0.4617
 Chest pain 52(23.3) 46(27.4) 6(10.9) 0.0015
Objective
 Feverd 133(59.6) 96(57.1) 37(67.3) 0.1838
 Hypothermiae 21(9.4) 15(8.9) 6(10.9) 0.6625
 Tachycardiaf 118(52.9) 84(50.0) 34(61.8) 0.1275
 Tachypneag 156(70) 109(64.9) 47(85.5) 0.0039*
 Hypoxiah 167(74.9) 114(67.9) 53(96.4) < .0001*
 Hypotensioni 27(12.1) 14(8.3) 13(23.6) 0.0025*

aSymptoms of cough, shortness of breath, chest pain, sore throat, and congestion were grouped as respiratory;

bGI symptoms were nausea, vomiting, diarrhea, abdominal pain;

csystemic symptoms were fever, myalgias, rash, encephalopathy, dizziness.

Abbreviations: bGI, gastrointestinal

dFever was defined as the highest temp of >38C;

ehypothermia as the lowest temp of <36C;

ftachycardia was defined as having a heart rate of >100 beats per minute;

gtachypnea was defined as having a respiratory rate of >20 breaths per minute;

hhypoxia was defined as having an O2 saturation of <95% on room air;

ihypotension was having a systolic blood pressure of <90mm Hg.

*p-values of <0.05