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. 2021 Jun 18;16(6):e0252411. doi: 10.1371/journal.pone.0252411

Table 6. Laboratory values during the first 24 hours of admission.

n (%) or median [IQR]
All patients Non-severe disease Severe disease p-value
n = 223 n = 168(%) n = 55(%)
Leukocytosisa 28(12.6) 20(12.1) 8(14.8) 0.4967
Leucopeniab 21(9.4) 14(8.4) 7(13.0)
Normal WBC 171(76.7) 132(79.5) 39(72.2)
Lymphopeniac 136(61) 98(59.4) 38(70.4) 0.2991
Thrombocytopeniad 48(21.5) 38(22.9) 10(18.5) 0.6189
ALT> 45 IU/Le 40(17.9) 29(21.2) 11(24.4) 0.6451
AST> 42 IU/Le 53(23.8) 35(25.6) 18(40.0) 0.0641
Elevated BUNf 57(25.6) 38(22.9) 19(35.2) 0.0733
Elevated creatinineg 54(24.2) 36(21.7) 18(33.3) 0.0841
eGFR<60h 76(34.1) 50(30.5) 26(48.2) 0.0182*
Hyponatremiai 97(43.5) 70(41.7) 27(49.0) 0.3350
Hypokalemiaj 61(27.4) 50(30.1) 11(20.4) 0.3787
Hypocalcemiak 54(24.2) 38(22.9) 16(29.6) 0.4558
Elevated troponinl 32(14.3) 21(16.7) 11(25) 0.2234
Hypoalbuminemiam 40(17.9) 23(16.8) 17(37.8) 0.0116*
Elevated CRPn 112(50.2) 86(90.5) 26(100) 0.1028
Elevated D-dimero 43(19.3) 28(43.8) 15(71.4) 0.0277*
Elevated Ferritinp 74(33.2) 51(82.3) 23(95.8) 0.1032
Elevated LDHq 73(32.7) 54(68.4) 19(86.4) 0.0951

Abbreviations: heGFR, estimated glomerular filtration rate; gAKI/ CKD, acute kidney injury/ chronic kidney injury; fBUN, blood urea nitrogen

aLeukocytosis is defined as WBC> 11x10exp9/L;

bleucopenia is defined as WBC< 3.5x10exp9/L;

clymphopenia is defined as <1x10exp9/L;

dthrombocytopenia is defined as platelet count below 150x10exp9/L;

felevated BUN defined as >24 mg/dl;

gElevated creatinine defined as serum creatinine>1.27 mg/dl;

ihyponatremia is defined as serum sodium<135mEq/L;

jhypokalemia is defined as serum potassium < 3.5mEq/L;

khypocalcemia is defined as serum calcium< 8.5 mEq/L;

lelevated troponin is defined as troponin of >0.06ng/ml;

mhypoalbuminemia is defined as serum albumin of <3.5 g/dl;

nelevated CRP (C-reactive protein) is defined as >10mg/L;

oelevated D-dimer is defined as >300ng/mL;

pelevated ferritin is defined as >120 ng/ml;

qelevated LDH defined as >220 IU/L

oD-dimer was missing in 138 patients; pferritin was missing in 137 patients; qLDH was missing in 122 patients; nCRP was missing in 102 patients; ltroponin was missing in 53 patients; eALT, eAST, malbumin was missing in 41 patients;

heGFR was missing in 5 patients;

clymphocyte count was missing in 4 patients; WBC count, dplatelet count, ecreatinine, fBUN, kcalcium, and jpotassium was missing in 3 patients

*p-values of <0.05