Table 2. Summary of impacts of compounds on healthy volunteer and keloid fibroblasts.

Summary of impacts of the glycolysis inhibitor (2DG), the mitochondrial ATP inhibitor (rotenone), caffeine, allicin, and shikonin on scratch assay healing time, extracellular acidification rate (ECAR), mitochondrial ATP production (Mito-ATP), non-Mito-ATP, the proinflammatory interleukin (IL-)6, and the neutrophil chemokine CXCL1.

Stimulant	EMT	ECAR	Mito-ATP	Non-Mito-ATP	IL-6	CXCL1
Healthy volunteer fibroblast cell line
2DG	___	↓	___	↓	↓	↓
Rotenone	___	___	↓	___	↓	___
Caffeine	↓	___	↓	↓	___	___
Allicin	↓	___	↓	↓	↓	↓
Shikonin	↓	___	___	___	___	↓
Keloid fibroblast cell line
Keloid derived (vs HV-FB)	↑	↑	↓	___	↑	↓
2DG	↓	↓	___	↓	↓	↓
Rotenone	___	___	↓	___	↓	___
Caffeine	↓	___	↓	↓	___	___
Allicin	↓	___	↓	↓	↓	↓
Shikonin	↓	___	↓	___	↓	↓