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. 2021 Jun 18;16(6):e0253521. doi: 10.1371/journal.pone.0253521

Table 3. Characteristics of studies that compared muscle damage between traditional high-load resistance exercise and high-load resistance exercise with blood flow restriction.

Reference Sujects (Age) Variable Training protocol Intensity Traininig volume Interval Pressure CW (cm) Results
EX MT TS Sets Repetitions RT+BFR (Time effect) Control (Time effect) Condition effect
Curty et al. (2017) [36] 9 men (26±1 years) DOMS, ROM, Edema AF Uni. 3s 130% of 1RM 3 10x10x10 60s 80% of AOP 14 DOMS ↔
ROM ↓ (Post)
Edema ↔
DOMS ↔
ROM ↓ (0,24h Post)
Edema↑ (Post)
DOMS was no different between conditions. Edema was higher after control (Post). ROM was similar immediately after the conditions (Post), but it was lower 24h after control.
Behinger et al. (2018) [40] 20 men (25±3 years) CK, DOMS, ROM, Edema. KE Uni. 1s/2s (ECC/CON) 75% of 1RM 4 Muscle failure 30s 20 mmHg below the AOP 13 CK↑ (24h post)
DOMS ↑ (24h post)
ROM↓ (0,20 min, 2,24h post)
Edema ↑(0,20 min, 2,24h post)
CK↑ (24h post)
DOMS ↑ (24h post)
ROM↓(0,20 min, 2,24h post)
Edema ↑(0,20 min, 2,24h post)
There were no differences in any of the variables analyzed between the conditions.

EX = exercise; MT = mode of training; TS = training speed; CW = cuff width; RT + BFR = resistance training with blood flow restriction; 1RM = 1 maximum repetition; KE = knee extension; AF = arm flexion; ECC = eccentric; CON = concentric; AOP = arterial occlusion pressure; mmHg = millimeters of mercury; CK = creatine kinase; DOMS = Delayed onset muscle soreness; ROM = Range of Motion.