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. 2021 Jun 18;16(6):e0252547. doi: 10.1371/journal.pone.0252547

Fig 4. Caloric restriction (CR) improves glucose intolerance and insulin sensitivity during aging.

Fig 4

Fifty-two-week-old mice were fed either ad libitum (AL) or treated with caloric restriction (CR) and analyzed on reaching 80 weeks of age. (A) Changes in body weight during the time course. (B) eVAT weights of the AL and CR mice. (C) Results of OGTT and ITT in WT mice fed AL or CR. (D) Serum levels of insulin, adiponectin, and leptin in the AL and CR mice. *P < 0.05. Data are represented as the mean ± SEM.