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. 2021 Jun 4;9:641603. doi: 10.3389/fcell.2021.641603

FIGURE 5.

FIGURE 5

MSTRG.24008.1 regulates the regeneration of SNI in vivo. (A) GMG in the SNI + MSTRG.24008.1 siRNA group increased significantly. Student’s t-test, **P < 0.01. Data are represented as the means ± SD. (B) Rat footprint function assessment (n = 6). (C) The SFI from (B) were measured using statistical analysis. Student’s t-test, **P < 0.01. Data are represented the means ± SD. (D) TEM showing that the myelin sheath thickness and axon diameter of SNI increased after MSTRG.24008.1 siRNA treatment (n = 6). (E) The myelin sheath thickness and axon diameter in (D) measured using Image-Pro Plus 6.0 software. Student’s t-test, *P < 0.05, **P < 0.01. Data are represented as the means ± SD. (F) Sciatic nerves analyzed using H&E staining. (G) Sciatic nerves analyzed using TUNEL staining. (H) The number of apoptotic cells in (G) were counted. Student’s t-test, *P < 0.05, **P < 0.01. Data are represented as the means ± SD. Scale bar: 5 μm in (D), 50 and 10 μm in (F), and 20 μm in (G). Data are representative of at least three independent experiments.