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. 2021 Jun 18;7(25):eabd8936. doi: 10.1126/sciadv.abd8936

Fig. 9. High CCL21 expression by cancer cells is associated with increased TILs and reduced risk of distant recurrence in human breast cancer.

Fig. 9

(A and B) T cell infiltrates in human breast cancers with high and low CCL21 levels. Bar graphs show (A) CD3+ T and (B) CD8+ T cell counts in human breast cancers. Each bar represents single breast cancer. Cell counts were based on 8 to 10 randomly selected hpf images. n = 7 in each group. Mann-Whitney U test was used. Graphs show means + SD. (C) Representative images of CCL21 immunohistochemical staining and CD3 and CD8 IF-stained human breast cancer tissues. (D) Representative images of CCL21 immunohistochemical staining on HR+ lymph node–positive (LN+) human breast cancer TMA samples and its correlation with distant recurrence rate. n = 265. clinical characteristics of TMA samples are listed in table S1. Log-rank test was used. Scale bars, 100 μm.