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. 2021 Jun 18;7(25):eabe2846. doi: 10.1126/sciadv.abe2846

Fig. 9. Models: Possible sources of replication forks that collapse upstream of TerA and their associated repair HJs.

Fig. 9

(A) Model: oriC-initiated replication leading to one-ended DSBs and HJs upstream of TerA. This is the major source. Black lines, template DNA strands; solid blue lines, nascent strands from the first round of replication; solid purple lines, nascent strands from a second round of replication; arrow heads, 3′ ends; dotted blue or purple lines, nascent strand during BIR repair. (B) Model: An alternative minor source of forks leading to DSBs and HJs upstream of TerA: BIR forks triggered by the repair of DSBs from unresolved catenanes at dif.