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. 2021 Jun 4;9:657621. doi: 10.3389/fcell.2021.657621

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Copyright © 2021 Yang, Wu, Zhou, Wu, Yao, Heng, Zhou, Liu and Ouyang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Three phases of tendon healing and the matrix changes during the healing process. Tendon healing goes through three phases, including inflammation (A), proliferation (B), and remodeling (C). In the inflammation phase, immune cells and fibroblasts from peritenon and epitenon migrate into injured position. In the proliferation phase, fibroblasts proliferate and angiogenesis occurs in this time. In the remodeling phase, repaired tendon has disordered matrix. The injured tendon finally forms tendon fibrosis and adhesion.