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. 2021 Jun 4;9:659417. doi: 10.3389/fcell.2021.659417

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Copyright © 2021 Rao, Yu, Sheng, Lv and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagram for biogenesis and functions of circFOXO3. (A) As shown, FOXO3 is located in chromosome 6q21 in human, and the red line is used to represent the approximate position of it. FOXO3 contains nine exons and only part of them is shown in this figure. circFOXO3 is formed by reverse splicing of exon 2, containing 1435 nucleotides (chr6:108,984,657–108,986,092). (B) CircFOXO3 forms ternary complex by combining CDK2 and P2 and the cell cycle is blocked in S phase. (C) CircFOXO3 promotes the regulation of FOXO3 on apoptosis by reducing FOXO3 ubiquitination. (D) CircFOXO3 adsorbs miRNAs and weakens the negative effect of the latter on gene expression.