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. 2021 Jun 4;11:657320. doi: 10.3389/fcimb.2021.657320

Table 4.

Analysis of administration modalities for faecal transplant.

Method Strength Weakness
Fresh faecal solution through nasogastric tube

  • - Preparation is easier and

  • - takes less time

  • - Invasive

  • - uncomfortable for the patient

  • - storage is a problem
Local “stool bank” from frozen faecal solution

  • - more flexible than fresh FMT

  • - has to be thawed before use
Freeze-drying the full sample

  • - lyophilisation provides longer storage time and

  • - lower storage requirements

  • no secondary centrifuge step is needed

  • - convenient to the patients

  • - lyophilisation adds 36 hours to the sample preparation time

  • - larger volume than the sediment/supernatant
Freeze-dried supernatant

  • - low volume

  • convenient to the patients

  • - lyophilisation provides longer storage time and

  • - lower storage requirements

  • - time consuming

  • - secondary centrifuge step needed
Freeze-dried sediment

  • - low volume

  • - convenient to the patients

  • - lyophilisation provides longer storage time and

  • - lower storage requirements

  • - time consuming

  • - secondary centrifuge step needed
Hard gelatine capsules

  • - low volume

  • - convenient to the patients

  • - lyophilisation provides longer storage time and

  • - lower storage requirements

  • - time consuming
Enterosolvent capsules

  • - convenient to the patients

  • - lyophilisation provides longer storage time and

  • - lower storage requirements

  • - can provide better efficacy?

  • - time consuming

  • - due to the smaller capsule size, more capsules are necessary than from hard gelatine capsules

  • - special capsules
Frozen FMT capsules

  • - convenient to the patients

  • - faster preparation

  • - larger volume

  • - special capsules

FMT, Faecal Microbiota Transplantation.