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. 2021 Jun 4;12:690681. doi: 10.3389/fendo.2021.690681

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Copyright © 2021 Al Rifai, Susan-Resiga, Essalmani, Creemers, Seidah and Ferron

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Furin inactivation in osteoblasts, osteocytes and hematopoietic cells did not impair FGF23 processing following erythropoietin injection. Plasma FGF23 measurements in 8-week-old Furin^flox/flox (n=7), Furin^osb-/- (n=5), Furin^osb-/- (n=5) and Furin^osb;BM-/- (n=6) male and female mice 6 hours following injection of vehicle or 3000 U/kg of recombinant human erythropoietin (rhEPO): C-terminal FGF23 (A), intact FGF23 (B), percentage (%) of intact over C-terminal FGF23 (C) and cleaved FGF23 levels (D), calculated as (C-terminal FGF23) - (intact FGF23). Results represent the mean ± SEM. *P < 0.05 and ***P < 0.001, by 2-way ANOVA with Bonferroni’s multiple comparisons test.