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. 2021 Jun 4;12:690681. doi: 10.3389/fendo.2021.690681

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Copyright © 2021 Al Rifai, Susan-Resiga, Essalmani, Creemers, Seidah and Ferron

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PACE4 inactivation in mice does not impair FGF23 processing. Plasma FGF23 measurements in 4-month-old Pcsk6 +/+ (n=4) and Pcsk6 -/- (n=4) male mice before (T0) and 6 hours following the injection of 50 ng/g of IL-1β: C-terminal FGF23 (A), intact FGF23 (B), percentage (%) of intact over C-terminal FGF23 (C), and cleaved FGF23 levels (D), calculated as (C-terminal FGF23) - (intact FGF23). Results represent the mean ± SEM. *P < 0.01, **P < 0.01 and ***P < 0.001, by 2-way ANOVA with Bonferroni’s multiple comparisons test.