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Poly-IC and its derivatives
| Poly-IC | Poly-ICLC (Hiltonol) | Poly-IC12U (Ampligen) | |
|---|---|---|---|
| Targeted receptors | MDA-5, TLR3 | MDA-5, TLR3 | TLR3 |
| Immune profile | Th1 | Th1 | Th1 |
| Resistance to serum nucleases | Not resistant | Resistant | Not resistant |
| Relative stability | + + | + + + | + |
