Table 2.
Relapse-free survival (RFS) and overall survival (OS) rate according to Univariate and Multivariate Cox regression analyses of prognostic factors of 114 patients with triple-negative breast cancer (TNBC)
| Clinicopathological feature | RFS | OS | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
| HR (95.0% CI) | P value* | HR (95.0% CI) | P value* | HR (95.0% CI) | P value* | HR (95.0% CI) | P value* | |
| Age (<60 vs. ≥60) | 0.523 (0.209–1.308) | 0.166 | 0.564(0.225–1.413) | 0.222 | ||||
| Tumor size (2 cm vs. >2 cm) | 2.491(1.051–5.905) | 0.038* | 2.616(1.082–6.330) | 0.033* | 2.710(1.139–6.452) | 0.024* | 2.849(1.166–6.962) | 0.022* |
| Histological grade (I, II vs. III) | 2.666(0.785–9.055) | 0.116 | 2.582(0.760–8.770) | 0.128 | ||||
| Histology (IDC vs. ILC, other types) | 0.590(0.173–2.007) | 0.398 | 0.600(0.176–2.040) | 0.413 | ||||
| Mib-1 (<20% vs. ≥20%) | 2.176(0.500–9.464) | 0.300 | 2.379(0.542–10.448) | 0.251 | ||||
| TLS (absent vs. present) | 0.776(0.283–2.124) | 0.621 | 0.772(0.283–2.112) | 0.615 | ||||
| iTILs (low vs. high) | 0.598(0.244–1.468) | 0.262 | 0.565(0.230–1.390) | 0.214 | ||||
| sTILs (low vs. high) | 0.330(0.111–0.988) | 0.048* | 0.563(0.169–1.877) | 0.349 | 0.332(0.111–0.992) | 0.048* | 0.569(0.168–1.933) | 0.366 |
| iCD20 (low vs. high) | 0.273(0.080–0.928) | 0.037* | 0.373(0.106–1.310) | 0.124 | 0.273(0.080–0.929) | 0.038* | 0.377(0.108–1.320) | 0.127 |
| sCD20 (low vs. high) | 0.287(0.110–0.746) | 0.010* | 0.363(0.136–0.969) | 0.043* | 0.265(0.102–0.690) | 0.007* | 0.330(0.124–0.880) | 0.027* |
| iCD38 (low vs. high) | 0.388(0.142–1.061) | 0.065 | 0.396(0.145–1.083) | 0.071 | ||||
| sCD38 (low vs. high) | 0.280(0.102–0.764) | 0.013* | 0.323(0.109–0.960) | 0.042* | 0.292(0.107–0.799) | 0.017* | 0.342(0.113–1.037) | 0.058 |
| iCD138 (low vs. high) | 1.173(0.492–2.794) | 0.719 | 1.193(0.502–2.838) | 0.689 | ||||
| sCD138 (low vs. high) | 0.446(0.184–1.082) | 0.074 | 0.455(0.187–1.105) | 0.082 | ||||
TNBC triple-negative breast cancer, RFS relapse-free survival, OS overall survival, HR hazard ratio, CI confidence interval, IDC invasive ductal carcinoma, ILC invasive lobular carcinoma, TLS tertiary lymphoid structures, i intratumoral, s stromal, TILs tumor-infiltrating lymphocytes
*p value is significant