Table 3:
Main results of pooled ORs in meta-analysis of MTHFR polymorphisms and CLL
| Genetic model | Test of association | Test of heterogeneity | Test of publication bias | |||
|---|---|---|---|---|---|---|
| C677T polymorphism | OR | 95% CI | I2 (%) | P | T | P |
| Dominant model | 0.99 | 0.85–1.15 | 0.0 | 0.785 | 0.01 | 0.990 |
| Recessive model | 0.89 | 0.69–1.14 | 35.7 | 0.143 | −0.22 | 0.835 |
| Allelic model | 0.97 | 0.86–1.08 | 0.0 | 0.470 | −0.08 | 0.939 |
| TT vs. CC | 0.90 | 0.69–1.16 | 35.1 | 0.148 | −0.21 | 0.838 |
| CT vs. CC | 1.02 | 0.87–1.19 | 0.0 | 0.841 | −0.33 | 0.756 |
| A1298C polymorphism | ||||||
| Dominant model | 1.00 | 0.85–1.18 | 0.0 | 0.473 | 1.53 | 0.265 |
| Recessive model | 1.05 | 0.79–1.38 | 39.6 | 0.147 | 1.17 | 0.362 |
| Allelic model | 1.12 | 1.01–1.25 | 57.9 | 0.068 | 1.85 | 0.205 |
| CC vs. AA | 1.04 | 0.88–1.45 | 47.3 | 0.128 | 1.26 | 0.336 |
| AC vs. AA | 1.00 | 0.84–1.19 | 0.0 | 0.843 | 1.38 | 0.303 |