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. 2021 Jun 18;6:86. doi: 10.1038/s41541-021-00348-x

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021

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Fig. 1 — a Experimental design of in vitro stimulation of T cells isolated from the blood of patients with HPV6 or HPV11-driven RRP or healthy donors with PRGN-2012. Concentrations of b IFNγ, c granzyme B, and d GM-CSF in the supernatant of cocultures assessing HPV antigen-specific responses in T lymphocytes isolated from the blood of patients with HPV11-driven RRP (n = 3, black bars), HPV6-driven RRP (n = 2, gray bars), or healthy donors (n = 3, open bars) following two rounds of in vitro simulation with PRGN-2012 or empty GC46. Displayed results are the result of HPV antigen-specific stimulation after baseline cytokine concentrations following in vitro stimulation with empty GC46 were subtracted. Similar results were observed in two independent assays. PBMC peripheral blood mononuclear cells, DC dendritic cells, HD healthy donor, empty GC46 GC46 gorilla adenovirus without HPV gene inserts (control virus). **p < 0.01; ***p < 0.001; Student’s t test.