Fig. 2. No toxicity was observed following in vivo vaccination with PRGN-2012.

Wild-type C57BL/6 mice were vaccinated with three doses of PRGN-2012 (10¹⁰ VP), empty GC46 (10¹⁰ VP), or FFB. a Body weight was assessed serially in vaccinated mice (n = 5 male and 5 female mice/group). 24 h after the final vaccination with PRGN-2012, empty GC46, or FFB, b organs were harvested and weighed and c plasma/serum was collected for chemistries (n = 5 male and 5 female mice/group). For chemistries, units of reported measurements are listed for each test on the x-axis. FFB final formulation buffer.