Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 18;11:12866. doi: 10.1038/s41598-021-90149-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Proteomic analysis of patients following PF-04691502 treatment. (a) Heatmap showing protein abundance changes of patients most and least sensitive to PF-04691502. Red indicates an increase in protein abundance, while green a decrease in protein abundance. (b) Graph showing the biological processes associated with the most and least sensitive patients. (c) List of the top ten proteins with increased abundance in the least sensitive patients. The associated biological function, fold change and p-value are also shown. Proteins were designated by p-value and arranged hierarchically by fold change. (d) List of the top ten proteins with decreased abundance in the least sensitive patients. The associated biological function, fold change and p-value are also shown. Proteins were designated by p-value and arranged hierarchically by fold change. (e) ROC analysis for top five statistically significant proteins with an increased abundance for the least sensitive patients to PF-04691502, including the calculated AUC, standard error (SE) and 95% confidence interval (CI). (f) ROC analysis for the top five statistically significant proteins with a decreased abundance for the least sensitive patients to PF-04691502, including the calculated AUC, standard error (SE) and 95% confidence interval (CI).