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. 2021 Jun 18;11:12903. doi: 10.1038/s41598-021-92303-y

Table 1.

Correlations of COL4A1 and COL4A2 to BM proteins and VSMC markers in human ITAs (graphical representation of correlations are shown in Supplementary Fig. 4).

Protein COL4A1 COL4A2
R2 p Slope (95%) R2 p Slope (95%)
BM
HSPG2 0.21 0.0006 0.17 (0.08–0.27) 0.30 < 0.0001 0.31 (0.19–0.44)
LAMA5 0.15 0.0035 0.20 (0.07–0.34) 0.24 < 0.0001 0.39 (0.21–0.57)
LAMB2 0.32 < 0.0001 0.27 (0.16–0.38) 0.35 < 0.0001 0.43 (0.27–0.58)
LAMC1 0.47 < 0.0001 0.41 (0.29–0.53) 0.44 < 0.0001 0.57 (0.40–0.73)
VSMC
CNN1 0.26 < 0.0001 0.47 (0.25–0.70) 0.44 < 0.0001 0.89 (0.62–1.16)
TAGLN 0.27 < 0.0001 0.60 (0.32–0.87) 0.28 < 0.0001 0.89 (0.51–1.26)
MYH11 0.40 < 0.0001 0.37 (0.24–0.49) 0.60  < 0.0001 0.65 (0.51–0.79)
TPM2 0.31 < 0.0001 0.42 (0.23–0.61) 0.38 < 0.0001 0.76 (0.49–1.03)
ACTA2 0.09 0.0372 0.24 (0.01–0.46) 0.22 0.0004 0.53 (0.25–0.81)
MYL9 0.30 < 0.0001 0.42 (0.24–0.60) 0.39 < 0.0001 0.70 (0.47–0.92)
Other
GAPDH 0.03 0.2480 0.11 (-0.08–0.29) 0.04 0.1392 0.19 (-0.06–0.45)