Table 1.
Correlations of COL4A1 and COL4A2 to BM proteins and VSMC markers in human ITAs (graphical representation of correlations are shown in Supplementary Fig. 4).
Protein | COL4A1 | COL4A2 | ||||
---|---|---|---|---|---|---|
R2 | p | Slope (95%) | R2 | p | Slope (95%) | |
BM | ||||||
HSPG2 | 0.21 | 0.0006 | 0.17 (0.08–0.27) | 0.30 | < 0.0001 | 0.31 (0.19–0.44) |
LAMA5 | 0.15 | 0.0035 | 0.20 (0.07–0.34) | 0.24 | < 0.0001 | 0.39 (0.21–0.57) |
LAMB2 | 0.32 | < 0.0001 | 0.27 (0.16–0.38) | 0.35 | < 0.0001 | 0.43 (0.27–0.58) |
LAMC1 | 0.47 | < 0.0001 | 0.41 (0.29–0.53) | 0.44 | < 0.0001 | 0.57 (0.40–0.73) |
VSMC | ||||||
CNN1 | 0.26 | < 0.0001 | 0.47 (0.25–0.70) | 0.44 | < 0.0001 | 0.89 (0.62–1.16) |
TAGLN | 0.27 | < 0.0001 | 0.60 (0.32–0.87) | 0.28 | < 0.0001 | 0.89 (0.51–1.26) |
MYH11 | 0.40 | < 0.0001 | 0.37 (0.24–0.49) | 0.60 | < 0.0001 | 0.65 (0.51–0.79) |
TPM2 | 0.31 | < 0.0001 | 0.42 (0.23–0.61) | 0.38 | < 0.0001 | 0.76 (0.49–1.03) |
ACTA2 | 0.09 | 0.0372 | 0.24 (0.01–0.46) | 0.22 | 0.0004 | 0.53 (0.25–0.81) |
MYL9 | 0.30 | < 0.0001 | 0.42 (0.24–0.60) | 0.39 | < 0.0001 | 0.70 (0.47–0.92) |
Other | ||||||
GAPDH | 0.03 | 0.2480 | 0.11 (-0.08–0.29) | 0.04 | 0.1392 | 0.19 (-0.06–0.45) |