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. 2021 Jun 18;12:3781. doi: 10.1038/s41467-021-23977-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Multiple sequence alignment was generated by the ConSurf algorithm (https://consurf.tau.ac.il) using the chain A of the SARS-CoV-2 spike protein in the closed state (PDB ID 6VXX) as a reference. Amino acid conservation scores were classified into nine levels. Structure of the SARS-CoV-2 S protein (chain A) with amino acid residues colored according to conservation on a scale from green (1, most variable) to dark purple (9, most conserved) is also shown.