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. 2021 Jun 18;4:761. doi: 10.1038/s42003-021-02239-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a–d PER2::LUC bioluminescence amplitude was significantly reduced by SVE in the WT dorsal only SCN (doSCN; pink filled D diagram insert) and ventral only SCN (voSCN; blue filled diagram insert) microdissected mini slices (dorsal: 19.2 ± 4.8 vs. 6.5 ± 2.4 arbitrary units, p = 0.018; ventral: 18.0 ± 5.6 vs. 5.0 ± 1.3, p = 0.017) but was boosted by SVE in the Vipr2^−/− voSCN (6.4 ± 1.4 vs. 10.7 ± 1.3; p = 0.041, all t tests). SVE did not alter amplitude in the Vipr2^−/− doSCN (4.6 ± 1.5 vs. 5.1 ± 1.2; p > 0.05). Period (g, h) was not altered by SVE in either part of the SCN for either genotype. Gray shaded boxes in e–h represent the interquartile distance between the upper and lower quartile with the median plotted as a horizontal line within the box. Whiskers depict the lower quartile − 1.5 × interquartile distance and upper quartile + 1.5 × interquartile distance. Individual data points are overlaid. *p = 0.05. Symbol color coding in f–h is as shown in e. a, c, e, g show data from doSCN. b, d, f, h show data from vo SCN. See also Figs. S3 and S4. D and V in diagram inserts label dorsal SCN and ventral SCN, respectively.