Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 18;12:3780. doi: 10.1038/s41467-021-24035-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — a m⁶A level of mRNA in HeLa cells overexpressing HA-tagged PRMT1 or GFP control. Data are mean ± s.d. from three independent experiments. Two-sided Student’s t-test. b m⁶A level of mRNA in HeLa cells after siRNA-mediated knockdown of PRMT1. Data from two independent experiments are shown. c m⁶A level of mRNA in WT, Prmt1^-/-, and PRMT1 overexpressed Prmt1^-/- mESCs. Data are mean ± s.d. from three independent experiments. Two-sided Student’s t-test. d MeRIP-qPCR analysis of m⁶A peaks on indicated genes in WT and Prmt1^-/- mESCs. Data are mean ± s.d. from four independent experiments. Two-sided Student’s t test. e m⁶A level of mRNA in WT and METTL14 R255K mESCs after the over-expression of GFP or PRMT1. Data are mean ± s.d. from three independent experiments. Two-sided Student’s t-test. Source data for (a–e) are provided as a Source Data file.