Table 4.
Prognostic factors for mortality in patients with SJS-ILD assessed using a Cox proportional hazards model.
| Characteristics | HR | 95% CI | P value | HR | 95% CI | P value | |
|---|---|---|---|---|---|---|---|
| Unadjusted analysis | Multivariable analysis | ||||||
| Age, years | 1.095 | 1.036–1.158 | 0.001 | Age, years | 1.158 | 1.050–1.278 | 0.003 |
| Female sex | 1.011 | 0.226–4.520 | 0.988 | ||||
| Ever-smokers | 3.206 | 1.117–9.202 | 0.030 | ||||
| CRP | 1.294 | 1.111–1.507 | 0.001 | CRP | 1.212 | 1.004–1.462 | 0.045 |
| BMI | 0.993 | 0.840–1.173 | 0.931 | ||||
| FVC, % predicted | 0.958 | 0.924–0.993 | 0.021 | FVC, % predicted | 0.902 | 0.839–0.969 | 0.005 |
| DLCOa, % predicted | 0.963 | 0.932–0.995 | 0.022 | ||||
| TLC*, % predicted | 0.949 | 0.912–0.989 | 0.012 | ||||
| Treatment with steroid ± IM | 0.840 | 0.236–2.986 | 0.788 | ||||
| UIP on HRCTb | 7.418 | 2.322–23.693 | 0.001 | UIP on HRCT | 4.580 | 1.167–17.975 | 0.029 |
BMI body mass index, CI confidence interval, CRP C-reactive protein, DLCO diffusing capacity of the lung for carbon monoxide, FVC forced vital capacity, HR hazard ratio, HRCT high-resolution computed tomography, ILD interstitial lung disease, IM immunosuppressants, SJS Sjögren syndrome, TLC total lung capacity, UIP usual interstitial pneumonia.
aBaseline DLCO and TLC were not included in the multivariable analysis due to their close correlation with FVC (vs. DLCO, correlation coefficient = 0.710, P < 0.001; vs. TLC, correlation coefficient = 0.873, P < 0.001).
bUIP to non-UIP.