Table 6.
The Relationship Between SUA Quartiles and IFG, Insulin Resistance, and Beta-Cell Dysfunction in Relevant Subgroups
| IFG | Insulin Resistance | Beta-Cell Dysfunction | |||||||
|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p value | p for Interaction | OR (95% CI) | p value | p for Interaction | OR (95% CI) | p value | p for Interaction | |
| Age | |||||||||
| ≤50 | 1.28(0.77–2.13) | 0.341 | 0.623 | 1.63(1.33–2.02) | <0.001 | 0.385 | 0.77(0.60–0.98) | 0.031 | 0.135 |
| >50 | 1.64(0.99–2.70) | 0.055 | 1.49(1.14–1.95) | 0.004 | 1.30(0.99–1.71) | 0.064 | |||
| Drinking | |||||||||
| No | 1.79(1.12–2.87) | 0.015 | 0.478 | 1.54(1.26–1.90) | <0.001 | 0.880 | 0.97(0.77–1.22) | 0.780 | 0.314 |
| Yes | 1.37(0.78–2.42) | 0.273 | 1.46(1.10–1.95) | 0.010 | 1.19(0.88–1.61) | 0.262 | |||
| Smoking | |||||||||
| No | 1.83(1.14–2.94) | 0.013 | 0.744 | 1.67(1.37–2.03) | <0.001 | 0.558 | 0.95(0.76–1.17) | 0.616 | 0.084 |
| Yes | 1.28(0.73–2.24) | 0.397 | 1.14(0.83–1.58) | 0.414 | 1.39(0.98–1.96) | 0.064 | |||
| BMI | |||||||||
| <24 | 1.59(1.00–2.54) | 0.050 | 0.348 | 1.44(1.16–1.78) | 0.001 | 0.070 | 1.12(0.90–1.40) | 0.321 | 0.381 |
| ≥24 | 2.05(1.11–3.80) | 0.022 | 1.94(1.48–2.55) | <0.001 | 0.86(0.62–1.20) | 0.380 | |||
| Hypertension | |||||||||
| No | 1.55(1.02–2.36) | 0.041 | 0.264 | 1.47(1.22–1.77) | <0.001 | 0.203 | 1.09(0.88–1.33) | 0.434 | 0.177 |
| Yes | 1.54(0.75–3.13) | 0.236 | 1.51(1.03–2.21) | 0.034 | 0.98(0.65–1.48) | 0.921 | |||
| Dyslipidemia | |||||||||
| No | 0.89(0.45–1.76) | 0.728 | 0.144 | 1.42(1.09–1.84) | 0.009 | 0.550 | 1.03(0.78–1.36) | 0.839 | 0.611 |
| Yes | 1.88(1.17–3.01) | 0.009 | 1.60(1.27–2.03) | <0.001 | 1.15(0.88–1.49) | 0.307 | |||
Notes: All ORs were adjusted for age (continuous), drinking (yes/no), smoking (yes/no), living area (urban/rural), carbohydrate intake (continuous), fat intake (continuous), protein intake (continuous), BMI (continuous), eGFR (continuous), hypertension (yes/no), dyslipidemia (yes/no) except for each stratifying factor. ORs and 95% CI were presented for individuals with SUA levels in the highest quartile compared to those in the lowest quartile.
Abbreviations: OR, odds ratio; CI, confidence interval; SUA, serum uric acid; IFG, impaired fasting glucose.