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. 2021 Jun 14;14:2673–2682. doi: 10.2147/DMSO.S312489

Table 6.

The Relationship Between SUA Quartiles and IFG, Insulin Resistance, and Beta-Cell Dysfunction in Relevant Subgroups

IFG Insulin Resistance Beta-Cell Dysfunction
OR (95% CI) p value p for Interaction OR (95% CI) p value p for Interaction OR (95% CI) p value p for Interaction
Age
 ≤50 1.28(0.77–2.13) 0.341 0.623 1.63(1.33–2.02) <0.001 0.385 0.77(0.60–0.98) 0.031 0.135
 >50 1.64(0.99–2.70) 0.055 1.49(1.14–1.95) 0.004 1.30(0.99–1.71) 0.064
Drinking
 No 1.79(1.12–2.87) 0.015 0.478 1.54(1.26–1.90) <0.001 0.880 0.97(0.77–1.22) 0.780 0.314
 Yes 1.37(0.78–2.42) 0.273 1.46(1.10–1.95) 0.010 1.19(0.88–1.61) 0.262
Smoking
 No 1.83(1.14–2.94) 0.013 0.744 1.67(1.37–2.03) <0.001 0.558 0.95(0.76–1.17) 0.616 0.084
 Yes 1.28(0.73–2.24) 0.397 1.14(0.83–1.58) 0.414 1.39(0.98–1.96) 0.064
BMI
 <24 1.59(1.00–2.54) 0.050 0.348 1.44(1.16–1.78) 0.001 0.070 1.12(0.90–1.40) 0.321 0.381
 ≥24 2.05(1.11–3.80) 0.022 1.94(1.48–2.55) <0.001 0.86(0.62–1.20) 0.380
Hypertension
 No 1.55(1.02–2.36) 0.041 0.264 1.47(1.22–1.77) <0.001 0.203 1.09(0.88–1.33) 0.434 0.177
 Yes 1.54(0.75–3.13) 0.236 1.51(1.03–2.21) 0.034 0.98(0.65–1.48) 0.921
Dyslipidemia
 No 0.89(0.45–1.76) 0.728 0.144 1.42(1.09–1.84) 0.009 0.550 1.03(0.78–1.36) 0.839 0.611
 Yes 1.88(1.17–3.01) 0.009 1.60(1.27–2.03) <0.001 1.15(0.88–1.49) 0.307

Notes: All ORs were adjusted for age (continuous), drinking (yes/no), smoking (yes/no), living area (urban/rural), carbohydrate intake (continuous), fat intake (continuous), protein intake (continuous), BMI (continuous), eGFR (continuous), hypertension (yes/no), dyslipidemia (yes/no) except for each stratifying factor. ORs and 95% CI were presented for individuals with SUA levels in the highest quartile compared to those in the lowest quartile.

Abbreviations: OR, odds ratio; CI, confidence interval; SUA, serum uric acid; IFG, impaired fasting glucose.