Table 1.
Population pharmacokinetic parameters describing QDs disposition characteristics in blood (CL: clearance; V1: volume of distribution in central compartment; V2: volume of distribution in peripheral compartment; Q: the inter-compartmental clearance, CV: coefficient of variation, T1/2: elimination half-life).
| Parameters | Final model estimate | % CV |
|---|---|---|
| CL (L/h) | 0.0416 | 12 |
| V1 (L) | 0.0027 | 9 |
| Q (L/h) | 0.498 | 21 |
| V2 (L) | 0.068 | 17 |
| Proportional error | 0.0686 | 8 |
| Additive error (ng/L) | 0.05 (38%) | 12 |
| T1/2 (min) | 28 | - |