Table 2.

Expression of significantly changed proteins (CTRL versus FRDA) versus molecular and clinical features of FRDA

Protein	Sampling age	Age of onset	FARS score	GAA1	GAA2	FXN mRNA (RNA-Seq)
ALDH1A3	0.25	0.18	−0.17	−0.06	−0.02	0.06
Integrin b3	0.12	0.19	−0.24	−0.16	−0.06	0.02
KIT-c	−0.17	−0.31	0.22	0.33	0.20	−0.28
p-p44/42MAPK (ERK1/2) (T202/Y204)	0.05	−0.02	0.09	0.05	0.04	−0.08
PHGDH	0.05	0.07	−0.12	−0.09	−0.07	0.40
AOX1	0.26	0.37	−0.33	−0.24	0.11	0.34
FOXO1	0.08	0.26	−0.36	−0.26	−0.17	0.18
p-BAD (S112)	−0.04	−0.01	−0.18	−0.04	−0.04	0.03
BCL2	−0.13	−0.22	0.25	0.23	0.16	−0.08
Era	−0.01	0.05	0.07	0.04	0.13	−0.01
p-AKT (T308)	0.04	0.03	0.07	0.10	−0.08	−0.04
BAD	−0.03	−0.03	−0.17	−0.05	0.02	−0.05
p27/KIP1	0.02	0.09	−0.32	−0.32	−0.30	0.23
p-SRC (Y527)	−0.10	0.06	−0.45	−0.03	0.17	0.11
p-STAT3 (S727)	0.11	0.18	−0.13	−0.08	0.03	0.12
IDH2	−0.03	−0.32	0.17	0.33	0.27	−0.42
STAT1	0.09	0.09	−0.05	−0.04	0.23	−0.03
p-p70S6K (T389)	−0.05	0.01	−0.04	−0.25	0.02	0.12
ATM	0.07	0.14	−0.01	−0.02	0.17	−0.07
SIN3b	−0.05	−0.05	−0.01	0.08	0.10	0.09
MED12	−0.16	−0.04	0.06	0.08	−0.07	0.06
AKT	0.06	0.20	0.06	0.09	0.26	0.01
EZH2	0.24	0.19	0.22	0.22	0.08	0.05
Integrin a4	0.10	0.34	−0.38	−0.09	0.01	0.43
RRM2	0.25	0.24	0.23	0.18	0.17	−0.03
p-Rb (S807/811)	0.09	0.06	0.33	0.20	0.19	−0.01
CHAF1A	0.25	0.18	0.14	0.22	0.14	0.03
DKK1	0.01	0.33	0.01	0.15	0.30	−0.08
WNT5a/b	−0.16	−0.18	0.14	0.07	−0.12	−0.19
FXN	0.22	0.30	−0.24	−0.43	−0.23	0.62

Pearson correlation coefficient values (r) are shown for each comparison. Values of r ≥ |0.3| are highlighted in bold and r ≥ |0.5| are highlighted in italics.