Numbers of patients with hookworm, pinworm, and Clostridioides difficile who were treated (and not treated) with SOC prescription drugs are as follows. For hookworm, the numbers are 267 (360) patients in 2010 to 2011, 206 (413) patients in 2012 to 2013, 156 (385) patients in 2014 to 2015, and 219 (572) patients in 2016 to 2018. For pinworm, the numbers are 4283 (1007) patients in 2010, 4915 (1286) patients in 2011, 4207 (2121) patients in 2012, 1917 (2810) patients in 2013, 1551 (3300) patients in 2014, 1322 (2849) patients in 2015, 1218 (3076) patients in 2016, 1234 (2940) patients in 2017, and 807 (2064) patients in 2018. For C difficile, the numbers are 2383 (1070) patients in 2010, 3393 (1320) patients in 2011, 4057 (1461) patients in 2012, 3663 (1418) patients in 2013, 4010 (1501) patients in 2014, 4188 (1403) patients in 2015, 4317 (1411) patients in 2016, 3625 (1136) patients in 2017, and 2502 (740) patients in 2018. The changes over time were tested by using the comparison between 2010 and 2018 data. Among the samples, the proportions of female patients were 52.2% for hookworm, 62.5% for pinworm, and 64.5% for C difficile. Mean ages for patients with hookworm, pinworm, and C difficile were 32.7, 13.1, and 42.0 years, respectively. Patients older than 65 years were excluded from the analysis to avoid issues with Medicare coinsurance payments, as mentioned in the eAppendix in the Supplement. Error bars denote 95% CIs.