. 2021 Jun 17;27:101057. doi: 10.1016/j.bbrep.2021.101057

Table 3.

Effect of Ruzu herbal bitters (RHB) on some serum oxidative stress markers of alloxan-induced diabetic rats.

Oxidative stress markers expressed in mean ± S.D
GROUPS	SOD (U/L)	CAT (U/L)	GPx (U/L)	GSH (mg/dl)	MDA (mg/mL)	VIT C (mg/dl)	VIT E (mg/dl)	CRP (mg/dl)
GROUP 1	11.08 ± 0.44^a	10.83 ± 0.60^a	67.52 ± 0.75^e	2.50 ± 0.16^ab	4.77 ± 0.19^a	0.60 ± 0.04^a	1.95 ± 0.07^a	1.30 ± 0.11^a
GROUP 2	11.72 ± 0.25^b	17.70 ± 0.1 6^e	56.34 ± 1.28^a	2.19 ± 0.22^a	5.59 ± 0.11^d	5.59 ± 0.11^d	2.14 ± 0.06^c	1.70 ± 0.02^c
GROUP 3	11.22 ± 0.11^a	11.62 ± 0.36^b	62.06 ± 0.98^c	2.34 ± 0.12^ab	4.99 ± 0.28^ab	0.61 ± 0.05^a	2.00 ± 0.06^ab	1.40 ± 0.05^ab
GROUP 4	11.40 ± 0.21^a	15.18 ± 0.32^d	59.59 ± 0.66^b	2.33 ± 0.29^ab	5.28 ± 0.20^c	0.64 ± 0.07^a	2.10 ± 0.03^bc	1.45 ± 0.04^b
GROUP 5	11.26 ± 0.13^a	14.05 ± 0.46^c	61.22 ± 1.73^bc	2.35 ± 0.11^ab	5.05 ± 0.14^bc	0.62 ± 0.03^a	2.02 ± 0.06^abc	1.38 ± 0.23^ab
GROUP 6	11.18 ± 0.20^a	11.83 ± 0.43^b	64.02 ± 2.91^d	2.41 ± 0.56^ab	4.84 ± 0.31^ab	0.59 ± 0.08^a	1.98 ± 0.11^ab	1.38 ± 0.23^ab
GROUP 7	11.12 ± 0.1 4^a	11.08 ± 0.38^a	65.97 ± 1.08^e	2.42 ± 0.79^ab	4.76 ± 0.23^a	0.59 ± 0.06^a	1.95 ± 0.16^a	1.29 ± 0.10^a
GROUP 8	11.13 ± 0.17^a	11.06 ± 0.04^a	65.82 ± 0.96^e	2.45 ± 0.38^ab	4.73 ± 0.15^a	0.60 ± 0.04^a	1.97 ± 0.18^ab	1.31 ± 0.04^a
GROUP 9	11.15 ± 0.30^a	11.02 ± 0.31^a	66.60 ± 1.02^e	2.77 ± 0.51^b	4.72 ± 0.17^a	0.59 ± 0.03^a	1.97 ± 0.13^ab	1.32 ± 0.03^a

Mean values with different letters as superscripts down the columns are considered significant (p < 0.05).

(^a-e Within a column, least square means without a common superscript differ (p < 0.05) due to variation of the tested parameter).

Group 1: normal control; Group 2: diabetic - untreated; Group 3: diabetic treated with 0.5 mg/kg b.w. of glibenclamide.

Group 4: diabetic treated with 0.14 ml/kg b.w. of RHB; Group 5: diabetic treated with 0.29 ml/kg b.w. of RHB.

Group 6: diabetic treated with 0.57 ml/kg b.w. of RHB; Group 7: non-diabetic treated with 0.14 ml/kg b.w. of RHB.

Group 8: non-diabetic treated with 0.29 ml/kg b.w. of RHB; Group 9: non-diabetic treated with 0.57 ml/kg b.w. of RHB.

SOD = superoxide dismutase, CAT = catalase, GPx = glutathione peroxidase, GSH = glutathione, MDA = malondialdehyde, VIT C = vitamin C, VIT E = vitamin E, CRP = C-reactive protein.