Table 5.

Association Between SNPs and Risk of Lung Cancer in Genetic Models

SNP	Model	Genotype	Control	Case	OR (95% CI)	p
rs13098637	Dominant	T/T	430 (71.7%)	387 (64.5%)	1	0.007*
		T/C-C/C	170 (28.3%)	213 (35.5%)	1.40 (1.09–1.78)
	Recessive	T/T-T/C	587 (97.8%)	576 (96%)	1	0.068
		C/C	13 (2.2%)	24 (4%)	1.87 (0.94–3.70)
	Log-additive	—	—	—	1.37 (1.11–1.70)	0.004*
rs3976523	Dominant	A/A	269 (44.8%)	243 (40.5%)	1	0.130
		A/C-C/C	331 (55.2%)	357 (59.5%)	1.19 (0.95–1.50)
	Recessive	A/A-A/C	537 (89.5%)	528 (88%)	1	0.410
		C/C	63 (10.5%)	72 (12%)	1.16 (0.81–1.67)
	Log-additive	—	—	—	1.14 (0.96–1.35)	0.130
rs4240897	Dominant	G/G	257 (42.8%)	321 (53.5%)	1	<0.001*
		G/A-A/A	343 (57.2%)	279 (46.5%)	0.65 (0.52–0.82)
	Recessive	G/G-G/A	530 (88.3%)	563 (93.8%)	1	<0.001*
		A/A	70 (11.7%)	37 (6.2%)	0.49 (0.32–0.75)
	Log-additive	—	—	—	0.67 (0.56–0.80)	<0.001*
rs2236058	Dominant	C/C	138 (23%)	179 (29.8%)	1	0.008*
		C/G-G/G	462 (77%)	421 (70.2%)	0.71 (0.54–0.91)
	Recessive	C/C-C/G	427 (71.2%)	485 (80.8%)	1	<0.001*
		G/G	173 (28.8%)	115 (19.2%)	0.59 (0.45–0.77)
	Log-additive	—	—	—	0.72 (0.61–0.85)	<0.001*
rs879255685	Dominant	G/G	393 (65.5%)	386 (64.3%)	1	0.680
		G/A-A/A	207 (34.5%)	214 (35.7%)	1.05 (0.83–1.33)
	Recessive	G/G-G/A	586 (97.7%)	574 (95.7%)	1	0.048*
		A/A	14 (2.3%)	26 (4.3%)	1.92 (0.99–3.72)
	Log-additive	—	—	—	1.11 (0.90–1.36)	0.320
rs879255689	Dominant	G/G	421 (70.2%)	381 (63.5%)	1	0.014*
		G/A-A/A	179 (29.8%)	219 (36.5%)	1.35 (1.06–1.72)
	Recessive	G/G-G/A	588 (98%)	575 (95.8%)	1	0.028*
		A/A	12 (2%)	25 (4.2%)	2.14 (1.06–4.30)
	Log-additive	—	—	—	1.36 (1.10–1.68)	0.005*

Note: *p < 0.05 indicates statistical significance.

Abbreviations: SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval.