Table 6.

Association Between SNPs and Risk of Lung Cancer in Smokers and Nonsmokers

SNP	Model	Genotype	Smokers		Nonsmokers
			OR (95% CI)	p	OR (95% CI)	p
rs13098637	Dominant	T/T	1	0.028*	1	0.130
		T/C-C/C	1.41 (1.04–1.93)		1.36 (0.91–2.02)
	Recessive	T/T-T/C	1	0.980	1	0.004*
		C/C	1.01 (0.42–2.46)		5.06 (1.42–18.03)
	Log-additive	—	1.31 (1.00–1.72)	0.052	1.47 (1.04–2.07)	0.026*
rs3976523	Dominant	A/A	1	0.320	1	0.230
		A/C-C/C	1.16 (0.87–1.54)		1.26 (0.87–1.84)
	Recessive	A/A-A/C	1	0.520	1	0.550
		C/C	1.17 (0.73–1.87)		1.19 (0.67–2.10)
	Log-additive	—	1.12 (0.90–1.40)	0.290	1.18 (0.89–1.56)	0.240
rs4240897	Dominant	G/G	1	0.014*	1	0.004*
		G/A-A/A	0.70 (0.52–0.93)		0.57 (0.39–0.84)
	Recessive	G/G-G/A	1	0.039*	1	0.002*
		A/A	0.60 (0.37–0.98)		0.30 (0.13–0.68)
	Log-additive	—	0.73 (0.59–0.91)	0.005*	0.57 (0.42–0.78)	<0.001*
rs2236058	Dominant	C/C	1	0.420	1	0.180
		C/G-G/G	0.88 (0.64–1.20)		1.40 (0.99–3.11)
	Recessive	C/C-C/G	1	0.012*	1	0.230
		G/G	0.65 (0.46–0.91)		1.35 (0.46–2.79)
	Log-additive	–	0.82 (0.67–0.99)	0.049*	1.81 (0.36–2.41)	0.140
rs879255685	Dominant	G/G	1	0.930	1	0.550
		G/A-A/A	1.01 (0.75–1.36)		1.13 (0.76–1.68)
	Recessive	G/G-G/A	1	0.680	1	0.052
		A/A	1.19 (0.51–2.80)		3.78 (1.22–11.71)
	Log-additive	—	1.03 (0.79–1.34)	0.840	1.26 (0.90–1.76)	0.170
rs879255689	Dominant	G/G	1	0.110	1	0.042*
		G/A-A/A	1.28 (0.95–1.72)		1.52 (1.01–2.30)
	Recessive	G/G-G/A	1	0.100	1	0.140
		A/A	2.20 (0.83–5.85)		2.08 (0.77–5.65)
	Log-additive	—	1.30 (0.99–1.70)	0.056	1.46 (1.03–2.06)	0.030*

Note: *p < 0.05 indicates statistical significance.

Abbreviations: SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval.